Molecular characteristics of inherited breast tumors

Molecular basis of inherited predispositions for tumors.

On the basis of literature data and own experience the authors review the current knowledge about the molecular basis of inherited predispositions for tumors. They hypothesize that in the near perspective 5-10 years studies using existing registry data/material and the latest novel technology will allow the identification of the molecular background for the majority of hereditary cancers which ...

Evaluation of Nucleostemin Gene Expression as a New Molecular Marker in Breast Tumors

Background & Aims: Nucleostemin is one of the stem cell enriched proteins which encodes a novel nucleolar GTP-binding protein found at high levels in the adult and embryonic stem (ES) cells but not in terminally differentiated cells. It is also expressed in tumor cell lines as well as in the several types of human cancers. Due to the increasing rate of breast cancer in recent years, in the pres...

S446 Molecular-genetic Characteristics of Thyroid Tumors

Genetic and Clinical Characteristics of Phyllodes Tumors of the Breast

PURPOSE Phyllodes tumors (PTs) of the breast are rare, accounting for less than 1% of all breast tumors. Among PTs, malignant PTs (MPTs) have malignant characteristics and distant metastases occur in about 20% to 30% of MPTs. However, there is no effective treatment for MPTs with distant metastasis, resulting in an abject prognosis. We performed targeted deep sequencing on PTs to identify the a...

Inherited Breast Cancer

During an eight-year period (January 1991– anuary 1999) a total of 11,200 women were xamined at the breast out-patient Department of he University Hospital. Of these, 7,750 were registered for the first time and 3,450 repeated their visit for different reasons. Of the 7,750 women, breast cancer was diagnosed in 261, who were treated appropriately. Out of the 261 breast cancer patients 9 (3.44%)...